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Evidence has shown their capability to increase the expression of NRF2 target genes in cellular and in vivo models of chronic obstructive pulmonary disease (COPD) [298], and to interfere with the direct PPI between KEAP1 and NRF2 or the PPI between KEAP1 and CUL3 [299, 300]

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OGTT can also be used if doubt remains as with patients with gestational diabetes Coding In Lothian we recommend using the umbrella code Pre-diabetes (WITH the hyphen)* # C11y5 Pre-diabetes You may also wish to consider an additional recall code such as: 66Az High risk of diabetes annual review** However, consideration should be given to frailty when considering using this code