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Spacing pizza meals to once weekly or twice monthly prevents digestive strain, since high-fat foods can cause nausea in some patients during dose escalation phases
Slow titration of dose can help, as can dietary adjustments. The recent mast cell paper suggested: significantly lower doses of GLP-1RAs than presently used as starting doses for T2DM and obesity therapy might be sufficient, and even optimal, for MCAS
However, some formulations contain additional ingredients that may be comedogenic for sensitive individuals
Haglund, M
The primary concern centers on gastrointestinal tolerability and safety
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