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Similarly, genes involved in cell cycle regulation and ECM organization, including those in the collagen biosynthesis and modifying enzymes pathway (ADAM metallopeptidase domain 12 ( Adam12) , laminin subunit beta 3 ( Lamb3 ), collagen type VI alpha 3 ( Col6a3 ), neurocan ( Ncan ) and integrin alpha 6 ( Itga6 )) also exhibited reduced expression

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It now appears that RIP1 expression was found to be significantly increased in cartilage from OA patients and rat models of OA, together with in vivo evidence pointing to intra-articular RIP1 overexpression being sufficient to trigger OA symptoms in rats (176178)

Committee Opinion No

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