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Insilico Medicine has nominated ISM9528, an orally available, brain-penetrant non-opioid candidate targeting a previously unrecognised pain mechanism, as its 31st AI-generated preclinical compound since 2021, with efficacy exceeding morphine in some preclinical models

Regulatory submissions are anticipated, with a potential approval timeline of 20262027 if the process proceeds smoothly

Quick reference table Further reading Peptide stability & lyophilisation review searches Peptide solubility & formulation review searches Internal links BPC-157 research material TB-500 research material GHK-Cu research material How to read an HPLC chromatogram Peptide storage & handling lab SOP Knowledge Hub Updated: 14 Nov 2025 Tide Labs supplies materials strictly for laboratory research use only