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9.1 Integrated discussion on mechanistic evidence strength, gaps, and confounding factors (1) Strength ranking of core mechanistic evidence and prioritization for clinical translation Based on a systematic analysis of each nutrient's regulatory pathway, the mechanisms with the strongest evidence for clinical translation are prioritized as follows: Omega-3 polyunsaturated fatty acids (EPA/DHA) anti-inflammatory pathway: Supported by human RCTs (65, 69), which show that EPA/DHA supplementation reduces the levels of pro-inflammatory cytokines (IL-1, IL-6) and improves depressive symptoms
Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer
While both compounds have almost identical functions, evidence has shown that SNAP-8 is more potent and effective than Argireline
For optimal results, consistent use over several weeks is recommended
GhezziAPozzilliCGrimaldiLMEBrescia MorraVBortolonFCapraRet al
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