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An 8-week double-blind randomized placebo-controlled trial in 62 patients with PWS demonstrated an improvement of hyperphagiaevaluated as behavior and severity scores by Dykens Hyperphagia Questionnaireafter Topiramate group versus placebo group, with no effects on BMI [95]

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Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation

It is approved by the MHRA for use in the UK and is prescribed under clinical oversight