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There are narrow Medicare coverage exceptions for these molecules: Semaglutide (Wegovy) is covered when prescribed for cardiovascular risk reduction in patients with established cardiovascular disease who are also overweight or obese

In a 52 week Phase 2 trial, overweight/obese individuals without diabetes lost 13.7% of their body weight (placebo subtracted) after receiving maridebart cafraglutide (420 mg once monthly), and overweight/obese individuals with diabetes lost 10.6% of their body weight and saw a decrease in HbA 1c of ~17 mmol/mol (1.5%, placebo subtracted) after receiving maridebart cafraglutide at the same dose (Table 2) [55]

6 (download XLSX Statistical source data for Extended Data Fig

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