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We think that the [neurons influence] on intervertebral disc degeneration is not only limited to the occurrence of pain, but also intervertebral disc degeneration itself, said Ximing Xu, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study

The global DNA methylation in the livers of HFD-fed mice was increased, with significant gene-specific hypermethylation of CYP2R1, CYP27A1, CYP27B1, and VDR, and hypomethylation of CYP24A1

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