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Concerning potential DDIs between NRT and anti-TB drugs, DrugBank.com reports that the metabolism of nicotine can be decreased when combined with INH or EMB and increased when co-administered with rifabutin

Human Brain Mapping, 36(11), 44974511

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Evening before bed is the dominant protocol because it amplifies the natural nocturnal GH surge (which peaks ~90 minutes into deep sleep)

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