Peterson, J., Schubert, D., Bemben, M., Campbell, J., and Black, C
V., Wagner, T
Researchers should note that AOD 9604s pharmaceutical development was discontinued due to insufficient efficacy findings in clinical trials, which is relevant context when evaluating either compounds utility in a research setting.
1,13 However, studies have found that 35% of patients experience local recurrences, suggesting that adjuvant radiation should be considered more broadly, particularly given the sensitive locations in which these neoplasms often arise that prohibit meaningful salvage operations
FA come preferentially from de novo synthesis via the glycolytic-lipogenic pathway via mitochondrial citrate transformation and not from exogenous FA uptake, as in Tregs [94, 95]