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Taken together, PNPLA2-mediated intracellular lipolysis promotes crosstalk between cancer cells and adipocytes and subsequently promotes tumor progression and aggressiveness

Tissue that was clearly damaged may demonstrate functional recovery

PubMed Seiwerth, S., Rucman, R., Turkovic, B., Sever, M., Klicek, R., Radic, B., Drmic, D., Stupnisek, M., Misic, M., Vuletic, L.B., & Sikiric, P

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Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration