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For those considering peptide therapy, this uncertainty itself is a safety risk: an impure or mislabeled product can cause unexpected reactions that confound reproductive plans

Kutlu SS, Cevahir N, Akalin S, et al

In light of current findings, it should be noted that LC combined with leucine or leucine alone supplementation does not improve the effectiveness of RET in healthy aged women, at least in studied doses

These concerns were put to rest by a clinical trial of very high doses of exenatide (the active ingredient in Bydureon), in which the drug was shown not to significantly affect heart rhythms

However, such patients reported being vigilant in avoiding their calories from dropping excessively low to avoid muscle loss