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Exogenous 1,alpha,25-dihydroxyvitamin D3 (DHD3), the biologically active metabolite of vitamin D3, can inhibit different experimental models of autoimmune disease and can significantly ameliorate EAE, the mouse multiple sclerosis. [105, 106] Experiments conducted in vitro and in vivo with both DHD3 and its synthetic analogue Ro 63-2023 showed specific inhibition of the Th1 cytokines IL-12 and IFN-gamma

The results demonstrated a no table increase in the clinical response, when compared to the placebo group over the four-week study period

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