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The beneficial effect of tirzepatide on hsCRP, a biomarker of systemic inflammation, YKL-40, a proinflammatory cytokine, and ICAM-1, a biomarker of endothelial dysfunction, was already detectable at 4 weeks, consistent with the salutary effects of GIP and GLP-1 on inflammation and atherosclerosis in experimental models [84,85,86]

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Antoszczyk S, Spyra M, Mautner V

Zhang Y, Qi Y, Li Y, Zhang Y, Zhao Y, Han H, Wang Y

Mercaptoacetic acid was dimerized in the presence of trifluoroacetic acid and acetone and then reduced with lithium aluminum hydride into the linker 2,2-(propane-2,2-diylbis(sulfanediyl))diacetic acid (synthetic strategy: Supplementary Fig