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The down-regulation of Nrf2 genes results in a decrease in antioxidant defense is due to the decreased expression of Nrf2-related antioxidant genes and thus, the oxidative stress induced by OTA may account for both the genetic damage and the cytotoxicy related to OTA [79]

Negative nitrogen balance occurs when digestion of body protein exceeds synthesis, and results from several circumstances, e.g., too little dietary protein

Impact of age-related genetic differences on the therapeutic outcome of papillary thyroid cancer

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Additionally, clinical trials involving natural products often face methodological issues such as inconsistent formulations, inter-individual variability among participants, and a need for large-scale studies to robustly assess therapeutic outcomes