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FIGURE 1 Intragastric administration of GRP (172 mg/kg body weight) to germ-free and human microbiota-associated (HMA) mice led to the excretion of approximately 30% unchanged GRP in the urine of both germ-free and HMA mice ( Figure 2 schematically demonstrates the metabolism of GRP and its biologically active derivative SFN within the GIT

Nature Communications (2016) 11

Taken together, these results are promising, suggesting that supplementation of carnosine or its precursors could have a beneficial effect on muscle strength, endurance, and improved functionality in elderly people

Glutathione has been discussed in scientific literature involving redox biology, oxidative stress research models, cellular metabolism, molecular signaling, biochemical pathway analysis, and controlled laboratory studies

In the case of miRNA therapies in RA, local delivery (intraarticular) might be beneficial, because a greater amount of active substance might reach the site of RA progression and possible systemic effects of miRNAs could be reduced