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IL-6 binds to TGF- to activate the STAT3 signaling pathway [20], inducing the expression of Th17 cell-specific principal transcription factor retinoic acid receptor-related orphan receptor gamma-t (RORt), thus differentiating into Th17 cells rather than Treg cells

The limited efficacy and potential adverse reactions of current treatments have led to a look for alternative strategies

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When You Should See a Specialist Or Stop Treatment If a clinician suspects a true allergic reaction, they may recommend stopping tirzepatide and referring to an allergist for testing, or initiating short-course corticosteroids or other targeted treatments

Office of Dietary Supplements, National Institutes of Health