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It was also reported in DRG neurons of wild type and TRPV4 knockout mice that activation of TRPV4 by paclitaxel induced mechanical allodynia and excessive ROS production, although the allodynia and oxidative stress was partially decreased by the TRPV4 antagonist treatment (Materazzi et al., 1)

Robinson, D.S., Ying, S., Bentley, A.M., Meng, Q., North, J., Durham, S.R., Kay, A.B., Hamid, Q., Relationship among numbers of bronchjoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacoline responsiveness in atopic asthma, J

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However, whether enteric glia express the enzymes necessary for glutathione synthesis and contribute to the protection against colitis in vivo is not known

Swirl gently