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At immature mossy-fiber-CA3 synapses, correlated presynaptic and postsynaptic activity persistently enhances GABA release and network excitability via BDNF and cAMP-dependent PKA

GLP-1 RAs improve CV outcomes, as well as secondary outcomes such as progression of renal disease, in patients with established CV disease or chronic kidney disease (CKD)

With the tip of the needle in the liquid, pull back on the plunger to get the right dose into the syringe

Suspected side effects should be reported via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

More future-facing interest: researchers tend to be most excited by compounds that expand the mechanism rather than simply optimize a known one