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This pharmacological distinction is important for researchers designing experiments that depend on sustained versus transient receptor activation

In this aspect, astrocytic terminal processes, known as endfeet, contact the brain vasculature and enwrap the neuronal synapses, enabling the modulation of both neuronal activity and cerebral blood flow, following an elevation in intracellular Ca 2+ levels in the endfeets [24,29]

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In fact, angiotensin-converting enzyme activity, and therefore local ATII concentrations are increased in atherosclerotic plaques, 65, 66 and inflammatory cells are capable of producing large amounts of ATII