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Severe dehydration can develop rapidly in patients experiencing significant gastrointestinal side effects from weight loss injections and may require intravenous fluid replacement

10.1111/j.1432-1033.1993.tb18025.x [DOI] [PubMed] [Google Scholar] Tagde A., Singh H., Kang M.H., and Reynolds C.P

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to conclude an MC4R agonist is not likely to produce clinically meaningful weight loss at well-tolerated doses, and the program was terminated after negative phase II results (48)

But GLP-1 medications have intentionally slowed your stomachs ability to do that