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Specifically, eligible studies included participants (P) with a confirmed diagnosis of vitamin B12 deficiency, interventions (I) involving oral or sublingual vitamin B12 administration, comparators (C) using intramuscular supplementation, and outcomes (O) reporting changes in serum vitamin B12 or homocysteine levels

additionally, more basic research is required to determine the primary pathophysiological mechanisms and the role of intestinal flora in PPI-induced IBD

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Faster than SSRIs, no tolerance like benzos, repairs neurons