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Zepbound (tirzepatide) is a dual GLP-1/GIP receptor agonist primarily approved for chronic weight management, and also for type 2 diabetes (as Mounjaro), working by enhancing insulin secretion, slowing gastric emptying, and reducing appetite

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This study found that the hazard of NAION was 3.24 times higher in individuals exposed to the GLP-1R agonists compared with those who were not, after adjusting for confounders

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