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1,4 Cobalamin deficiency leads to various clinical and metabolic consequences, including vomiting, diarrhoea, weight loss, failure to thrive, nerve disorders, immunodeficiency, and intestinal changes including poor absorption of nutrients and vitamins (including cobalamin itself)

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Due to these possible outcomes, incision or excision of plaque and grafting surgery is commonly performed in combination with placement of an inflatable penile prosthesis