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This is an important nuance: GLP-1 therapy, including orforglipron, is primarily a metabolic intervention
SGLT2 inhibitors (such as dapagliflozin, empagliflozin, or canagliflozin) promote urinary glucose excretion and may cause volume depletion
The supernatant was separated from the pellet by centrifugation at 4 C, 16,000 g , and incubated with chitin resin overnight with mild shaking at 4 C
H., Shin, J
[3][5][9] Women's Health Womens Health and Incretin Therapies Incretin therapies are not recommended during breastfeeding and pregnancy [3][5][9] women of childbearing potential should use contraception [27] For women planning pregnancy: [3][5][9] liraglutide: discontinue before attempting to conceive semaglutide: discontinue 2 months before attempting to conceive tirzepatide: discontinue 1 month before attempting to conceive Specific OCP advice for tirzepatide: [9] women with a normal BMI : no dose adjustment of OCP is required women with obesity or overweight : switch to a non-oral contraceptive method, or add a barrier method of contraception upon initiation or dose escalation of tirzepatide (for 4 weeks) Follow the British Menopause Societys tool for clinicians when considering prescribing incretin-based therapies in women using HRT
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