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These symptoms included progressive memory problems coupled with psychiatric disturbances

The designed system destabilized in endosome upon cleavage of cis-aconityl at low pH, leading to endosomal disruption with regenerated parent polycation and releasing mono-siRNA to circumvent immune system

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doi: 10.1016/j.clinthera.2018.12.016 556 GoldenbergDLSimmsRWGeigerAKomaroffAL

Together with still prominent lymphocytic infiltration and inflammation in progressive MS, being particularly pronounced in the meninges and perivascular spaces, leads some investigators to conclude that inflammation primarily drives demyelination and degeneration at all stages of this disease (Lassmann, 2018)