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It is an anti-fungal agent that has been repurposed for cancer treatment due to its ability to reverse chemoresistance and to inhibit hedgehog and mTOR signalling, angiogenesis and autophagy [43, 44]

This acidity changes the charge of the peptide molecules, causing them to repel each other rather than clump together

Gastrointestinal side effects, particularly nausea, vomiting, and diarrhea, can lead to reduced fluid intake and increased losses

Association of supraphysiological doses of GCs and increased bone resorption is supported by increase in serum level of resorption markers including tartrate-resistant acid phosphatase (TRAP), carboxy-terminal telopeptide of type I collagen (CTX), urinary calcium/creatinine, cAMP, urinary crossover, and soluble osteoclastogenic cytokine receptor interleukin-6 (sIL-6R ) [32]

This medication may come in the form of a pill, patch, implant, patch, or injection