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Defects in SDH subunits lead to succinate accumulation and oncometabolite-driven pseudohypoxia and are strongly linked to hereditary paragangliomas, pheochromocytomas and certain renal cell carcinomas, underscoring the essential role of complex II in metabolic and redox homeostasis 78,79

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In our study, the requirement of endogenous GLP-1R signaling to increase small intestinal length was only observed cold-stressed male, but not female mice, suggesting a sex difference in the identity or action of compensatory intestinotrophic signaling molecules

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has received research funding from Lilly, Novo Nordisk, Altimmune and Skye Bioscience