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Development was discontinued because the Phase IIb trial of 536 subjects over 24 weeks failed to meet its primary efficacy endpoint

Summary: Retatrutide commonly makes people feel reduced appetite and fullness after small meals, alongside gastrointestinal effects such as nausea, diarrhoea, and bloating, particularly during dose escalation

We used PH rats induced with MCT because it is the most classical and widely used in vivo model for nearly 60 years due to its simplicity, reproducibility and low cost [42]

Key differences A 10mg vial contains twice the peptide mass