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[5] [22] Signs of an allergic reaction could include rash, itching, swelling, or difficulty breathing

[4] Pregnant and breastfeeding women , particularly those following plant-based diets, require adequate B12 intake to support foetal development and prevent infant deficiency

[99] A person with cobalamin C disease, a rare autosomal, recessive, inheritance disease which results in combined methylmalonic aciduria and homocystinuria), [100] can be treated with intravenous or intramuscular hydroxocobalamin

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