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Insulin sensitivity pilot study (Ruggenenti): A pilot study in nondiabetic subjects at increased cardiovascular risk with insulin resistance found that 2 g/day of oral ALCAR for 6 months improved insulin-mediated glucose disposal (measured by euglycemic hyperinsulinemic clamp) alongside reductions in blood pressure [5][21]

Exp Physiol 108(5):661671

Some patients report improvement with probiotic supplements, though clinical evidence is limited

Insulin Resistance and Exendin-4 Treatment for Multiple System Atrophy

The human and animal-based clinical trials show that subjects have experienced benefits like longer life span, antioxidant effects, and timely circadian rhythms