In this context, our workflow for identifying antiviral targets, integrating cellular metabolism and data from virally infected cells, as well as the inhibitors we have identified, represents an invaluable resource for pandemic preparedness against future emerging pathogens
Several mechanisms explain how disruptions in gut health can influence weight and metabolic disease
The study was funded by the National Institutes of Health (grants R37MH63105, R01HL129795 and R21AI137319), the Howard Hughes Medical Institute, the Cystic Fibrosis Foundation and the German Research Foundation.
2019;67:e12584
Among 21,822 people of European ancestry, we required participants to have complete data needed to construct the target phenotype and GWAS covariates (that is, data available for pre-treatment weight, post-treatment weight, drug type, dosage, time on treatment and factors such as age, sex and height), resulting in 18,488 participants