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Achieving 10% or greater weight reduction at one year was associated with several factors such as semaglutide or liraglutide, obesity as a treatment indication as compared to T2D, female sex, persistent coverage for one year, and high or low dosage of medication

While glutamic acid is mainly involved in protein synthesis, neurotransmission, and nitrogen metabolism, glutamine plays a critical role in nitrogen transport and serves as a fuel source for rapidly dividing cells, such as immune and intestinal cells

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We estimated normalisation factors for each sample by applying the TMM method 62 on the count data for sgRNAs targeting a gold-standard set of non-essential genes 63

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