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Some patients report feeling unusually cold during their first weeks of treatment, a symptom tied directly to decreased caloric intake and changes in thermogenic (heat-producing) pathways

Thus dosage, pharmacokinetics, long-term safety, off-target effects in humans remain unknown

You can reduce fatigue by eating enough protein, staying hydrated, getting adequate sleep, and maintaining balanced nutrition

Oral cannabis products: If using oral cannabis products (edibles, oils), be aware that tirzepatide's effect on slowing gastric emptying may alter the onset and intensity of effects