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Although GLP-1RAs can attenuate inflammatory tone [105], sustained reductions in nutrient inflow associated with pharmacological weight loss may influence NAD turnover kinetics in metabolically stressed tissues

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If a patient has several metabolic conditions, poorly controlled diabetes, or a history of bariatric surgery, a specialist can offer more nuanced medication management

Since this study, several other publications highlighted the potential interest of Fisetin to treat different diseases related to senescence cells accumulation such as kidney fibrosis 20 or muscular dystrophy 21

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