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This tissue-specific response has been confirmed in vivo after analysing the ability of six plant-derived ITC (allyl-ITC, iberverin, erucin, SFN, iberin and cheirolin) to increase tissue levels of NAD(P)H:quinone oxidoreductase 1 and glutathione transferase in a variety of rat tissues at doses of 40 mol/kg per d

6-AH family members were found to act as mimics of the dimerization domain of FIGF (hinge region), and inhibited the interaction of an HGF molecule with a 3 H-hinge region peptide resulting in an attenuated capacity of HGF to activate its receptor Met

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