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Significant impairment of biliary copper transport can permit copper accumulation in the liver

And fifth, it sets clear benchmarks at weeks 12 and 24 to evaluate whether the current dose is delivering adequate results or needs adjustment

In the CY 2025 PFS final rule (89 FR 98081 through 98213), we finalized changes to Shared Savings Program policies, including to: sunset a requirement under which CMS would terminate an ACO's participation agreement, under certain circumstances, if it failed to maintain at least 5,000 assigned beneficiaries during an agreement period