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this leads to a malabsorption of the vitamin Certain medications use long term metformin use and chronic acid-reducing drugs decrease the absorption of vitamin B12 from food particles Malignancy of the pancreas or bowel Folic acid deficiency Semaglutide Semaglutide is contraindicated in patients with a history of angioedema, anaphylaxis, or other serious hypersensitivity reaction to semaglutide

it is frequently suggested for long-term deficiency cases

However, some people are prone to Vitamin B12 deficiencies

Abrupt cessation wont cause withdrawal symptoms or rebound effects, but metabolic markers will gradually return to baseline over 24 weeks as AMPK activity normalizes and NNMT inhibition wears off

Vitamin B12 Warnings Patients who have early Leber's disease (LHON) a hereditary disease that causes optic nerve atrophy have been found to suffer severe and swift optic atrophy when treated with vitamin B12