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Russell, D

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Concerns about the potential association between certain diabetes medications and cardiovascular disease meant that in 2010 the FDA approved liraglutide on condition that Novo Nordisk conduct a post-marketing study to evaluate the drug's effect on the incidence of major cardiovascular events (Nielsen, DeChiaro, Goldman)

7.4 Bariatric Surgery - The Outcome Benchmark Roux-en-Y gastric bypass produces mean percent total body weight loss of approximately 25-30% at one year, declining modestly to approximately 22-25% at five years with a wide distribution - 20.4% of RYGB patients fail to reach even 20% total body weight loss at five years in the SleeveBypass randomized trial

One large-scale study of 125,474 adults found that 64.8% of patients without type 2 diabetes stopped their GLP-1 treatment within a year , compared to 46.5% of patients with type 2 diabetes