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High intracellular glucose concentration develops when hyperthyroidism induces IR in GD patients, because brain cells like cerebral microvascular endothelial cells, pericytes, and astrocytes are unable to slow down their glucose transport rate (122, 123)

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The findings, published in the journal Diabetes, Obesity and Metabolism, provide real-world context to previous randomized clinical trials indicating that patients who stopped semaglutide (sold under the brand names Ozempic/Wegovy) and tirzepatide (sold under the brand names Mounjaro/Zepbound) regained more than half of the weight they lost within 12 months

Recently, its effectiveness in managing obesity has led to its approval for weight loss treatment