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This drew our attention to the ubiquitin-related protein UBE2m, which is a ubiquitin-conjugating enzyme essential for the neddylation that was significantly enriched (Fig

GR and GS can be stimulated even by lower concentrations (200 M and 400 M) indicating that glutathione metabolism in macrophages is tightly regulated in order to keep adequate GSH levels

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Acknowledgements Funding Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research centre, based at the University of Copenhagen, and partially funded by an unconditional donation from the Novo Nordisk Foundation ( grant no