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9 Use of DPP4-inhibitors in older frail populations Oral DPP-4 inhibitors have few notable side effects and are associated with a minimal risk of hypoglycaemia

Hind limb blood flow measurement with laser speckle imaging To assess endothelium-dependent vasodilation in the quadriceps muscle, five animals per group (WT and VECAD IGF- 1R KD) were anesthetized using isoflurane (induction 34%, maintenance 1.52%) in oxygen and mechanically ventilated to ensure stable respiration

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intermittent treatment with senolytics have conclusively reduced senescent cell burden in peripheral tissues (fat, lung, kidney, pancreas, cartilage, and muscle), improved pathologies in these tissues, and extended healthspan and lifespan (45, 46, 100-103)