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Fast forward to today, and GLP-1 receptor agonists, originally developed for diabetes, have proven their worth in inducing significant weight loss with mostly manageable side effects

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In addition to the improvement in HbA1c and glucose profile, tirzepatide has also demonstrated to improve insulin resistance, as assessed by HOMA-IR

Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronised progesterone versus placebo (KEEPS)

18 For those patients not achieving desired glycemic control at 1.2 mg, the dose can be increased to 1.8 mg