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Discontinuation rates due to AEs: - Placebo: 4.9% - 4 mg: 4.1% - 9 mg: 6.9% - 12 mg: 11.3% The 11.3% discontinuation rate at the highest dose is a number worth watching

People who are older, have kidney or liver issues, or take multiple medications may need slower titration

In contrast, immediate widespread reactions, progressive swelling, difficulty breathing, or systemic symptoms may indicate a more serious hypersensitivity reaction requiring urgent medical evaluation

The good news is that nausea tends to decrease significantly after the first two weeks on any given dose, as your body builds tolerance to the receptor activation

The researchers performed a retrospective observational study of over 150,000 adult patients over a nine-year period