It needs to be provided with a support of essential amino acids, mainly lysine and methionine together with iron and vitamins C, B3 and B6, in order to be synthesised
According to the classic two-hits model, the increased insulin resistance, secondary to metabolic syndrome, determines an excessive lipid accumulation in healthy hepatocytes (first hit), mainly through an increased mobilization of free fatty acids from visceral adipose tissue to the liver
J Physiol Pharmacol 2000, 51, 751-773
Biomarker Validation and Clinical Translation: The field must prioritize the validation of clinical biomarkers that accurately reflect ferroptosis activity (e.g., MDA, 4-HNE, extracellular ferritin)
[ref] Studies also show increased lactate in the cerebrospinal fluid in ME/CFS.[ref] Elevated lactate levels correlate with the presence of post-exertional malaise (PEM) .[ref] Related articles: Lactate and Pyruvate Changes in cardiac output and cerebral blood flow: A 2024 study showed that 91% of the ME/CFS patients in the study had an abnormal cardiac output and abnormal cerebral blood flow in response to going from lying down to standing up (tilt table)
