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Activated MZF1 induces expression of the lysosomal cysteine cathepsins B and L [47, 48] and several other cancer relevant genes [46], and interestingly also the expression of cholesterol transporter NPC1 leading to metabolic switch from cholesterol synthesis to cholesterol uptake and linking invasiveness to cholesterol uptake [7]
As our understanding of the role of oxidative stress in these conditions grows, glutathione may become a cornerstone of effective management strategies
85 SteynF
Weight loss through lifestyle intervention has long been shown to improve obesity-related metabolic factors and conditions coexisting with obesity
When faster or more effective healing is needed, evidence-based medical therapies include platelet-rich plasma (PRP) therapy, corticosteroid injections (with appropriate clinical guidance), approved anti-inflammatory medications, and in some cases, surgical intervention
