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This single event triggers three major downstream signaling pathways that collectively govern neuronal health: the MAPK/ERK pathway, the PI3K/Akt pathway, and the PLCgamma pathway

The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression

Gilman JT

The A549 cell line (adenocarcinomic human alveolar basal epithelial cells) was acquired from the American Type Culture Collection (ATCC, Manassas, VA, USA)

The induced Tregs are predominantly the IL-10 + cytotoxic-T-lymphocyte-associated antigen-4 (CTLA4) high Helios-subset with potent immunosuppressive activity, and they can migrate to extraintestinal organs to suppress systemic inflammation