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Induction of in vitro metabolic zonation in primary hepatocytes requires both near-physiological oxygen concentration and flux

Moreover, the antioxidant properties of melatonin play crucial roles in protecting oocytes from oxidative stress in vitro (92)

It did not affect CDNB concentration measured in the outflow perfusate collected from the cardiac atrium (means +/- SEM of 119 +/- 8 M and 168 +/- 34 M in vehicle- and DMF-treated animals, respectively), ruling out the possibility that the decreased concentration of toxicant in CSF following DMF treatment resulted from a decreased xenobiotic concentration in the choroidal vascular system in our experimental conditions

21,22 Another suggested hypothesis is that ethanol may directly enhance the activity of NAD(P)H:quinone reductase, serving to reconvert quinone metabolites back to native APAP and thereby limiting the accumulation of toxic metabolites