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Its main active ingredient, total dajizin triterpenes, reduces the expression of ACSL4 in the rat model of RA, increases the expression of glutathione and GPX4, and upregulates Kelch-like ECH-associated protein 1 and HO-1 in the Nrf2/HO-1/GPX4 pathway, indicating that total dajizin triterpenes can inhibit cell aberrant ferroptosis by suppressing lipid peroxidation and thus exert therapeutic anti-RA effects [168]
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Broad Therapeutic Effects : Tirzepatide results in clinically significant improvements in multiple obesity-related complications, including sleep apnea, metabolic dysfunction-associated steatohepatitis, heart failure with preserved ejection fraction, and diabetes prevention [79]
Psychiatry 58 , 361367 (2001)
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