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Under the dermis layer are fibrous septae , strong bands of tissue that pull down a small area of the skin, allowing fat cells to push up in other areas

moderate quality evidence) (El Sharkwy & Sharaf El-Din, 2019)

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A randomized, double-blind, placebo-controlled phase 2 study comparing the efficacy and safety of tirzepatide versus placebo in 196 patients with nonalcoholic steatohepatitis (SYNERGY-NASH) with or without diabetes is currently underway and is estimated to complete in 2024